Manchester United will be without Ryan Giggs, Gary Neville and Louis Saha for the Champions League Group F match against FC Copenhagen on Wednesday.
The club's web site said on Tuesday midfielder Giggs (hamstring), right back Neville (calf) and striker Saha (knee) will not travel with the squad to the Danish capital.
United, who have maximum points from three matches, will seal a place in the last 16 of the competition with a victory.
"It's a blow not to have such experienced players but we've got a big squad," United manager Alex Ferguson was quoted as saying on the club's web site.
Patrice Evra, who suffered an ankle injury in the 4-0 rout of Bolton Wanderers on Saturday that kept United top of the Premier League, has recovered in time to make the trip.
Wes Brown is likely to start in place of Neville while Ole Gunnar Solskjaer or Alan Smith could partner Wayne Rooney in attack.