Speaking to the NDTV Profit television channel, New York-based Nair revealed that she will begin shooting for the film, AIDS Jagao in Mumbai next month.
The four short films will be screened in theatres all over the country before the main feature is screened, Nair said.
Her film will star Saif Ali Khan, Shiny Ahuja and Vidya Balan. It is based on a script by Zoya Akhtar, whose brother Farhan directed last week's big release, Don.
This week, The Bill and Melinda Gates Foundation promised the Union health ministry $23 million to combat AIDS in India. Three years ago, the Foundation launched a $258 million anti-AIDS campaign in India.