Arsenal [ Images ] and Manchester United [ Images ] will be looking to make it four wins out of four in the Champions League [ Images ] this week after playing out an enthralling 2-2 draw in the Premier League on Saturday.
Arsenal will secure a berth in the last 16 with two games to spare if they beat Slavia Prague away and United can also progress to the knockout stages on Wednesday with a home win over Dynamo Kiev.
Unbeaten in all competitions this season, Arsenal are firm favourites to get the result they need after a breathtaking 7-0 demolition of Slavia at the Emirates last month.
Three points against Kiev will see United through if Sporting Lisbon [ Images ] fail to beat Roma at home and either way, Sir Alex Ferguson [ Images ] will hope to celebrate 21 years in charge at Old Trafford with a double over the Ukrainian champions.
Having welcomed Louis Saha's return from injury, Ferguson might consider fielding the Frenchman from the start alongside Wayne Rooney [ Images ], who has scored nine goals in his last eight matches for club and country.
Chelsea [ Images ] have notched up seven consecutive wins under Avram Grant [ Images ] in all competitions to get their season firmly back on track and an eighth at Schalke 04 tomorrow would put them in a strong position to advance from Group B.
Chelsea are top three points ahead of Rosenborg, who are away to Valencia, with the Spanish side and Schalke a further point adrift in a tight battle to avoid an early exit.
In contrast to Chelsea, Liverpool are hanging on by a thread and anything but a win against Besiktas at Anfield tomorrow would almost certainly end their hopes of progressing into the last 16.
Liverpool are bottom of Group A with one point from three matches and desperately need a result to keep their hopes alive and to end a patchy run in which they have won only two of their last seven matches.
HOME FORM
Holders AC Milan [ Images ] have found rival turfs in the Italian first division to be happier hunting grounds recently but it is their home form that put them joint top of Group D in Europe's premier club competition.
Milan, who have not won a Serie A game at the San Siro since April, travel to Shakhtar Donetsk, who share top spot on six points, after beating them 4-1 a fortnight ago while Celtic and Benfica [ Images ] have three each ahead of their clash in Glasgow.
Milan's city foes Internazionale should be confident of following up on their 2-1 win at CSKA Moscow [ Images ] with another success over the outgoing Russian champions on Wednesday that would leave them in the Group G driving seat.
Inter have six points followed by Fenerbahce on five and PSV Eindhoven on four with the latter two meeting in Istanbul to provide a stern test for PSV's caretaker coach Jan Wouters after Ronald Koeman's departure to Valencia.
Wouters needs to avoid another setback to keep PSV on course for a berth in the last 16 after starting his reign with a 2-1 league defeat at Heerenveen over the weekend, the team's first loss of the season in the Dutch Eredivisie.
Real Madrid [ Images ] will also be looking to bounce back from a domestic setback, a 2-0 loss at Sevilla, when they visit Olympiacos Piraeus tomorrow after overpowering the Greek side 4-2 at the Bernabeu [ Images ] a fortnight ago.
Barcelona [ Images ] are at home to Rangers on Wednesday after their goalless draw at Ibrox left them level on seven points at the top of Group E while Lyon, who trail them by four points, will hope to gain some ground when they entertain Vfb Stuttgart.

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