Michael Carrick [ Images ] and Robbie Keane are struggling with ankle injuries, Mido still has a knee problem while Paul Stalteri has joined Jermaine Jenas and Ledley King on the sidelines.
A Tottenham win guarantees fourth spot and a place in the Champions League [ Images ] qualifying rounds unless arch-rivals Arsenal [ Images ] beat Barcelona [ Images ] in the Champions League final on May 17.
Asked on Friday if midfielder Carrick would be fit, Jol told reporters: "We're hopeful. He didn't train today or this week but hopefully he can train tomorrow and will have a late test."
Jol also said he would reject any bids for Carrick, who has been linked with a move to Manchester United [ Images ].
Ireland striker Keane is unlikely to play after twisting his ankle in last week's win over Bolton Wanderers while Egypt [ Images ] forward Mido has not recovered from a knee problem.
"We'll try him (Keane) again tomorrow but I think it's still a 90/10 chance against that he'll make it," said Jol. "Mido hasn't trained for three weeks but we will try to do something tomorrow and have another late test."
Jermain Defoe [ Images ], in his first return to Upton Park since leaving for Spurs in January 2004, should be partnered up front by 21-year-old Lee Barnard who replaced Keane last Sunday.
HOSTILE RECEPTION
Defoe is likely to face a hostile reception, having angered West Ham fans by asking for a transfer immediately after they were relegated to the second division in 2003.
Jol believes the England [ Images ] striker can cope with the atmosphere.
"He's big enough to take it," said Tottenham's Dutch coach. "He's a good player. There's maybe only one or two players who get that sort of reception and I think (former West Ham midfielder) Michael Carrick will have the same to be honest."
Another Tottenham injury victim is Canada [ Images ] right back Stalteri, who is out with a knee problem.
Carrick's England team mates Jenas and King are unavailable with a shin injury and broken foot respectively.
The only good news is the return of Dutch midfielder Edgar Davids after suspension.
Spurs are a point above Arsenal with one game left and Arsene Wenger's [ Images ] team, who host Wigan Athletic in their final game at Highbury on Sunday, have a much better goal difference.
Jol considers Sunday's game his most important as a manager.
Asked if he would get the score relayed from Highbury, Jol said: "We have to focus on our own match and we have to win.
"It would be a dream scenario if we draw and they lose but I can't imagine that because Arsenal are playing so well."

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