Former champions Lleyton Hewitt [ Images ], Venus Williams [ Images ] and Serena Williams [ Images ] are also in action, while Belgian fourth seed Kim Clijsters [ Images ], the favourite for the women's title, meets Ai Sugiyama [ Images ] of Japan [ Images ] for a place in the last 32.
World number one and defending champion Federer, who is bidding to win his sixth grand slam title, meets the wily Fabrice Santoro [ Images ].
Federer has won six of their eight previous meetings and dropped just four games in beating the Frenchman in the first round at the Australian Open [ Images ] in January.
Australian Hewitt, the 2001 champion, meets Jose Acasuso of Argentina, while sixth seed Nikolay Davydenko [ Images ] of Russia [ Images ] and David Nalbandian [ Images ], the 11th seed from Argentina, are also in action.
Russian Sharapova, who has never been past the third round in New York, meets Julia Schruff of Germany [ Images ], and Serena Williams, the Australian Open champion and eighth seed, takes on Italian Francesca Schiavone, the 25th seed.
Wimbledon [ Images ] champion Venus Williams kicks off the night session when she faces Slovakian Daniela Hantuchova [ Images ], the 20th seed, having won all seven of their previous meetings.

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