There were also defeats for Gustavo Kuerten of Brazil [ Images ] and Argentina's Agustin Calleri, the other two seeds in action, while Russians Marat Safin [ Images ] and Yevgeny Kafelnikov both lost to Swedish opposition and Tim Henman [ Images ] went down to the American Mardy Fish [ Images ].
The best tennis of the day came in the final match up on centre-court, with Lopez edging out Philippoussis to strengthen his claims for a place in Spain's Davis Cup squad for the final against Australia [ Images ] later this year.
After two tight sets, Lopez made the crucial break in game eight to take a 5-3 lead, Philippoussis sending a backhand pass well wide on break-point.
Lopez then held serve confidently to complete victory in one hour 48 minutes and set up a third round match against either Carlos Moya [ Images ] or Gaston Gaudio.
Nicolas Massu [ Images ] of Chile had earlier upset 13th seed Gustavo Kuerten 6-3 7-5 to set up a potential third-round clash with American second seed Andy Roddick [ Images ], who plays his first match in the tournament against Max Mirnyi [ Images ] of Belarus on Wednesday.
Kuerten, the three-times French Open [ Images ] champion, outserved his opponent on centre-court but paid the price for a series of errors on crucial points.
"I couldn't make the right shots in the first set," Kuerten complained. "I was nervous... I had the chance to win the second set at 5-4 ahead but I made errors."
In the last match on court one, Calleri, seeded 12th, lost to the American Vincent Spadea 7-6 3-6 6-3.
CLEAR CHANCES
Safin had ample opportunities to win his first-round match against Jonas Bjorkman [ Images ] but his hopes of a first ATP Tour win since April were dashed by his more consistent opponent, who came from a set and a break down to win 4-6 7-5 6-4.
Safin, who has now lost all three of his matches since returning from a series of injuries, clinched the first set and moved confidently into a 2-0 lead in the second.
He became upset at a series of foot-fault calls, however, and Bjorkman capitalised on his loss of service rhythm to come back and level after a set lasting 68 minutes.
Bjorkman was a model of consistency in the decider and snatched victory in game 10, as Safin, serving at 4-5 down, put a forehand drive long on match-point.
Bjorkman's compatriot Thomas Enqvist had an easier route through against Kafelnikov, who was forced to retire after losing the first set 6-3.
The Swedes were joined in the second round by Fish, who outpunched Henman 7-6 6-3, with the Briton finding none of the form that marked his run to the semi-finals in Vienna [ Images ].

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