Damien Martyn's 95 not out and a five-wicket haul from spinner Brad Hogg helped Australia crush West Indies by 116 runs in the opening match of the triangular limited-overs series at Melbourne on Friday.
World champions Australia smashed 301 for four including half-centuries from Michael Clarke and Ricky Ponting before West Indies were dismissed for 185 in 46.2 overs.
Paceman Brett Lee (three for 36) put Australia firmly in control, removing Chris Gayle (0), Ramnaresh Sarwan (four) and Xavier Marshall (five) to peg back West Indies at 33 for four in the seventh over.
Captain Brian Lara (58) and Shivnarine Chanderpaul (46) rebuilt the innings with a 98-run partnership for the fifth wicket before the pair fell to left-arm spinner Hogg, who took a career-best five for 32 to win the man of the match award.
The series continues on Sunday when Australia host Pakistan in Hobart.
Martyn, who hit six fours and one six in his 93-ball innings, continued the stunning form he showed in 2004 when he hit six Test centuries.
The 33-year-old was on 93 with one over remaining but could manage only two singles to finish five runs short of his sixth century.
Opener Clarke hit 66 and Ponting also cashed in on the touring side's poor fielding, the Australian captain blasting 78 including five fours and one six.
Dwayne Bravo took a sensational diving catch at mid-wicket in the third over to remove Adam Gilchrist for a duck off the bowling of Ian Bradshaw.
Clarke, promoted to the top of the order after Matthew Hayden was rested, shared a 115-run stand with Ponting for the second wicket to put the home side on track for a big total.
Left-hander Darren Lehmann (20 not out) brought the Melbourne Cricket Ground crowd of 51,453 to their feet with a boundary through point off the final ball to lift the total over 300.
Unable to break into Australia's Test X1 for their last three series, Lee trapped Gayle leg before wicket from the third ball of the West Indies innings.
Wavell Hinds was run out for five before Lee had Sarwan and 18-year-old debutant Marshall caught behind fending off short balls.
Hogg claimed the key wicket of Lara caught at cover and in his next over he caught and bowled Chanderpaul to kill off the West Indies challenge at 136 for six.
The 33-year-old Hogg also removed Marlon Samuels (9) and Bravo (3) in his first spell of four for 22 from seven overs.
Hogg then had Bradshaw caught on the boundary for 12 to finish with his second five-wicket haul in his 53rd one-day international.
A.Gilchrist c Bravo b Bradshaw 0
M.Clarke b Samuels 66
R.Ponting run out 78
D.Martyn not out 95
A.Symonds c Gayle b Bradshaw 20
D.Lehmann not out 20
Extras (b-2 lb-5 w-11 nb-4) 22
Total (for four wickets, 50 overs) 301
Fall of wickets: 1-4 2-119 3-207 4-254
Did not bat: S.Watson, B.Hogg, B.Lee, J.Gillespie, M.Kasprowicz
Bowling: Bradshaw 10-1-46-2 (w-1), Dillon 8-0-69-0 (nb-4), Samuels 10-0-45-1 (w-2), W.Hinds 3-0-20-0, Gayle 3-0-21-0, Sarwan 8-0-49-0 (w-6), Bravo 8-0-44-0 (w-2).
C.Gayle lbw b Lee 0
W.Hinds run out 5
R.Sarwan c Gilchrist b Lee 4
B.Lara c Symonds b Hogg 58
X.Marshall c Gilchrist b Lee 5
S.Chanderpaul c and b Hogg 46
M.Samuels c and b Hogg 9
D.Bravo c Gilchrist b Hogg 3
C.Browne not out 20
I.Bradshaw c Clarke b Hogg 12
M.Dillon c Ponting b Kasprowicz 6
Extras (b-1 lb-13 w-3) 17
Total (all out, 46.2 overs) 185
Fall of wickets: 1-0 2-17 3-21 4-33 5-131 6-136 7-143 8-144 9-167
Bowling: Lee 10-1-36-3, Gillespie 8-0-29-0 (w-2), Kasprowicz 6.2-0-26-1 (w-1), Watson 7-0-37-0, Hogg 10-0-32-5, Symonds 5-0-11-0
Result: Australia won by 116 runs.
Next game: Australia v Pakistan, January 16, Hobart.