Pakistan, inspired by a second successive century by Kamran Akmal, crushed England by 165 runs in the third one-day international on Thursday.
England, chasing a massive victory target of 354, were bowled out for 188 in 42 overs on the way to a record-equalling defeat which left them 2-1 down in the series.
Pakistan's victory was inspired by wicketkeeper Akmal who followed up his 102 in the second match at Lahore with a sparkling 109.
The opener's third one-day hundred, made from only 111 balls and including 12 fours, powered Pakistan to a mammoth 353 for six before a sellout crowd despite stringent security measures.
England are the first non-asian team to play at the venue for five years due to security concerns.
England never recovered after Shoaib Akhtar ran out Matt Prior for two and in the next over seamer Rana Naved had Marcus Trescothick and Vikram Solanki caught in the slips for 32 and a duck.
Mohammad Sami reduced England to 79 for four by trapping Andrew Strauss lbw.
Andrew Flintoff struck three fours in one over from supersub Yasir Arafat and seven in his 36 from 41 balls but following his departure, bowled by Arafat, England crumbled quickly as spinners Shoaib Malik and Shahid Afridi shared five wickets.
England also lost to West Indies by 165 runs in 1992-93, their biggest losing one-day margin in runs.
Scorecard
Pakistan Innings
S. Butt c Flintoff b Plunkett 29
K. Akmal c Plunkett b Collingwood 109
Y. Khan c G. Jones b Plunkett 0
M. Yousuf run out 68
S. Afridi run out 31
Inzamam-ul-Haq b Flintoff 45
A. Razzaq not out 51
S. Akhtar not out 1
Extras (b-5 lb-1 w-13) 19
Total (for 6 wickets, 50 overs) 353
Fall of wickets: 1-74 2-84 3-188 4-234 5-272 6-350
Did not bat: Naved-ul-Hasan, M. Sami, S. Malik
Bowling: A. Flintoff 10 - 1 - 57 - 1 (w-1), J. Anderson 10 - 0 - 72 - 0 (w-3), S. Harmison 8 - 0 - 62 - 0 (w-2), L. Plunkett 7 - 0 - 61 - 2 (w-2), P. Collingwood 8 - 0 - 58 - 1 (w-1), I. Blackwell 5 - 0 - 25 - 0, V. Solanki 2 - 0 - 12 - 0
England Innings
M. Trescothick c Inzamam-ul-Haq b Naved-ul-Hasan 22
M. Prior run out 2
A. Strauss lbw b Sami 23
V. Solanki c Y. Khan b Naved-ul-Hasan 0
A. Flintoff b Arafat 36
P. Collingwood c Butt b Malik 19
G. Jones c Arafat b Afridi 14
I. Blackwell c Sami b Afridi 14
I. Bell not out 37
L. Plunkett b Malik 7
S. Harmison c Afridi b Malik 1
Extras (lb-7 nb-1 w-5) 13
Total (all out, 42 overs) 188
Fall of wickets: 1-22 2-40 3-40 4-79 5-101 6-122 7-140 8-145 9-186 10-188
Bowling: S. Akhtar 5 - 1 - 23 - 0 (nb-1 w-5), Naved-ul-Hasan 7 - 1 - 31 - 2, M. Sami 5 - 1 - 18 - 1, Y. Arafat 5 - 0 - 31 - 1, S. Afridi 10 - 0 - 42 - 2, S. Malik 9 - 1 - 29 - 3, A. Razzaq 1 - 0 - 7 - 0
Result: Pakistan won by 165 runs
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